Product Name :
Ubiquitin+1, Human
Product Type :
Protein
Lot No :
QMA02
Reactivity :
Human
Storage :
Shipped at 4°C. Store at -20°C. After reconstitution, store at -80°C and avoid frequent freeze and thaw.
Composition :
Lyophilized from 20mM HEPES, pH 7.4
Source :
Purified from E.coli expressing the human Ubuiquitin +1 gene (1-95aa, with N-GST tag)
Molecular Weight :
37 kDa
Endotoxin activity :
Not tested
Usage :
500ul of distilled water will yield a concentration of 1mg/ml.
Form :
Lyophilized
Purity :
> 95% by SDS-PAGE
Expression system :
E.coli
Tag :
GST tag
Origin :
Human
Background :
Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.
Background reference :
1) Van Leeuwen, F.W. et al. (1998) Science, 279, 242-247.
2) Van Leeuwen, F.W. et al. (1998) Trends Neurosci. 21(8), 331-335.
Research area :
Neuroscience 
Database link - SwissProt no.
P62988

The test was performed by customers with their own sample.