Product Name :
α-synuclein, Human
Product Type :
Protein
Lot No :
NJN0002
Storage :
Shipped at 4°C. Store at -20°C. After reconstitution, store at -80°C and avoid frequent freeze and thaw.
Composition :
Lyophilized from 20mM Tris, pH8.0, 10mM NaCl, 130mM imidazole
Source :
Purified from E.coli expressing the human alpha-synuclein gene (1-140aa, with N-His tag)
Molecular Weight :
16.7 kDa
Endotoxin activity :
Not tested
Form :
Lyophilized
Purity :
> 95% by SDS-PAGE
Expression system :
E.coli
Tag :
His tag
Origin :
Human
Background :
ynuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. alpha-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19 kDa that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson's disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation.alpha-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this alpha-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of alpha-Synuclein are associated with autosomal dominant Parkinson's disease. The mutations increase the aggregation rate of the resultant alpha-synuclein.
Background reference :
1) Wakabayashi K et al. 2007, Neuropathology 27(5):494-506.
2) Beyer K., 2006, Acta Neuropathol 112(3):237-251.
3) Bruening W et al., 2000, Cancer 88(9):2154-2163.
Research area :
Neuroscience 
Database link - SwissProt no.
P37840

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