Product Name :
Trail, human
Product Type :
Protein
Lot No :
OJE 01
Reactivity :
Human
Storage :
Shipped at 4°C. Store at -20°C. After reconstitution, store at -80°C and avoid frequent freeze and thaw.
Composition :
Lyophilized from 1X PBS (pH7.4)
Source :
Purified from E.coli expressing the human tumor necrosis factor ligand superfamily member 10 isoform 1 gene (95-281aa)
Molecular Weight :
21 kDa
Endotoxin activity :
Not tested
Form :
Lyophilized
Purity :
> 95% by SDS-PAGE
Expression system :
E.coli
Tag :
None
Origin :
Human
Background :
In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis.[1][2] TRAIL is a cytokine that is produced and secreted by most normal tissue cells. It causes apoptosis primarily in tumor cells,[3] by binding to certain death receptors. It has been used as a target of several anti-cancer therapeutics since the mid-1990s. These however have not shown significant survival benefit.[4] TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).[3]"
Background reference :
1) Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA (December 1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 (6): 673–82. doi:10.1016/1074-7613(95)90057-8. PMID 8777713.
2) Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (May 1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271 (22): 12687–90. doi:10.1074/jbc.271.22.12687. PMID 8663110.
3) TNFSF10. NCBI Gene.
Database link - SwissProt no.
P50591

The test was performed by customers with their own sample.