Product Name :
Diazepam Binding Inhibitor, Human
Product Type :
Protein
Lot No :
#0002
Storage :
Shipped at 4°C. Store at -20°C. After reconstitution, store at -80°C and avoid frequent freeze and thaw.
Composition :
Lyophilized from 20mM HEPES, pH 7.4
Source :
Purified from E.coli expressing the human DBI gene (1-87aa, with N-GST tag)
Molecular Weight :
38 kDa
Endotoxin activity :
Not tested
Form :
Lyophilized
Purity :
> 95% by SDS-PAGE
Expression system :
E.coli
Tag :
GST tag
Origin :
Human
Background :
Diazepam Binding Inhibitor (DBI) is a highly conserved 10 kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer’s disease.
Background reference :
1) Shoyab, M. et al (1986) J. Biol. Chem. 261: 11968-11973.
2) Gray, P.W. et al (1986) Proc. Nat. Acad. Sci. 83:7547-7551.
3) Ohkuma, S. et al (2001) Life Science 68: 1215-1222.
Research area :
Neuroscience 
Database link - SwissProt no.
P07108

The test was performed by customers with their own sample.