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Amyloid Beta Proteins

  Amyloid Beta 1-42 Oligomers (cat#SPR-488) and Pre-formed Fibrils (cat#SPR-487) 
show a dose-dependent toxicity to primary rat cortical neurons. Monomers are not toxic (cat#SPR-485).
Oligomers | Pre-formed Fibrils (PFF) | Monomers
Amyloid Beta
for Neurodegenerative Disease Research

Induce Amyloid Beta Toxicity with StressMarq’s Oligomers and Pre-formed Fibrils

Fibrils and respective vehicle controls 
were initially sonicated in a Bioruptor. 
Test conditions were run in the same 
plate as untreated control and vehicle 
controls, which consisted of buffer 
without amyloid beta 1-42 protein. 
Data expressed as mean +/- s.e.m. 
(n=6). A global analysis of the data was 
performed using a one-way ANOVA 
followed by Dunnett’s test; ** p<0.01 
stats vs control; ## p<0.01, #### 
p<0.0001 stats vs vehicle control. 
§ represents untreated control condition.
Oligomers Pre-formed 
Fibrils Monomers
Catalog# Product Name Available Sizes*
SPR-488 Amyloid Beta 1-42 Oligomers 100ug | 200ug | 500ug
SPR-487 Amyloid Beta 1-42 Pre-formed Fibrils 100ug | 200ug | 500ug
SPR-485 Amyloid Beta Peptide 1-42 (HFIP treated) 100ug | 500ug | 1mg

Internal Reference: YF-PA26408